Dr Harendra (Harry) S Parekh

Senior Lecturer & Research Group Leader – Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, Australia.

Email:h.parekh@uq.edu.au

Biography:


Dr Parekh obtained a Bachelor of Science in Pharmacy with 1st Class Honours from the University of Portsmouth, UK in 1997. Upon successful completion of his pre-registration internship with Boots The Chemists (London) he registered as a Pharmacist with the Royal Pharmaceutical Society of GB in 1998, and his membership remains current today.

In late 1998 Harry Parekh was awarded a BBSRC scholarship, enrolling in the PhD program at The University of Nottingham (UK) within the School of Pharmaceutical Sciences under the supervision of Dr B. Kellam and Dr S.R. Chhabra. He was awarded his PhD in Medicinal Chemistry in 2002, relocating to Australia in 2003.

From 2003-2005 Dr Parekh was a research fellow on a National Health and Medical Research Council (NHMRC) grant, developing novel non-viral vectors for gene delivery. In 2004 his technology for treating age-related macular degeneration was awarded the Trailblazer ‘Open Winner’ prize for commercial potential, by Uniquest Pty LTD.

In 2005 Dr Parekh attained Pharmacy Board registration in QLD (Australia). In the same year he was appointed Lecturer within the School of Pharmacy and set about establishing his own laboratory focusing his research on engineering advanced non-viral drug and gene delivery systems. In 2007, for the 2nd time, Dr Parekh was awarded the Trailblazer ‘Open Winner’ prize for his antibody targeted gene delivery system.

In 2009 Dr Parekh was appointed adjunct-Senior Lecturer at Manipal University, India, having also delivered invited seminars to key research and teaching institutions in Germany and Singapore with active collaborations spanning the globe also including the USA, Brazil and UK. To-date (2013) Dr Parekh has graduated 5 Honours, 2 Masters and 4 PhD students from his group, with his research being funded by the NHMRC, Deutscher Akademischer Austausch Dienst-Group of 8 Council, Cancer Council of Queensland, The University of Queensland, Australian Medical Association-QLD node and Uniquest Pty LTD.


Research Areas:

• Dendrimer-mediated drug & gene delivery
• Bubble liposomes in drug and gene delivery
• Transdermal drug/gene delivery
• Traditional Chinese Medicine into the 21st century
• Molecular dynamics simulation of gene-carrier systems

Research Interest:

The ‘nanotech’ age is firmly upon us and with this comes the exciting prospect that researchers will, in time, deliver on their promise to work towards innovative and practical therapeutic solutions against a wide range of acute and chronic diseases, which afflict both young and old alike. Research being conducted in the Parekh laboratory at the University of Queensland and Bio-Lab at NUSNNI (in collaboration with Assoc. Prof. Giorgia Pastorin) is dedicated to this cause, where a range of chemically-derived carrier systems are being systematically developed, holding much promise as vehicles for the safe and targeted delivery, as well as release of various drugs/genes in vivo.

Selected Publications:

Book title: DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases
Chapter title: Fluorescent nucleic acid probes in living cells
Anne Seefeld, Ganesh R Kokil, Karnaker R Tupally, Harendra S Parekh*, Dirk-Peter Herten*
Publisher: Springer Berlin Heidelberg (2013)
ISBN: 978-3-642-36852-3
Pages: 291-328.

Iontophoresis-Mediated Transdermal Permeation of Peptide Dendrimers across Human Epidermis
Mutalik S., Parekh H.S., Anissimov Y.G., Grice J.E., Roberts M.S.
Skin Pharmacology & Physiology. 2013; 26, 127-138.

Jing Jing; Wei C Ren; Si B Chen; Ming Q Wei; Harendra S Parekh*
Advances in analytical technologies to evaluate the quality of traditional Chinese medicines.
Trends in Analytical Chemistry, 2013, 44, 39-45.

Srinivas Mutalik*, Rohit Kalra, Usha Y Nayak, Aravind Kumar, Harendra S Parekh*
Sonophoresis induced permeation and retention of peptide dendrimers across human epidermis.
Skin Research & Technology, 2012, 18, 101-107.

Jing Jing, Chi-on Chan, Lijia Xu, Dengping Jin, Xinwei Cao, Daniel K.W. Moka, H.S. Parekh, Sibao Chen*
Development of an in-line HPLC fingerprint ion-trap mass spectrometric method for identification and quality control of Radix Scrophulariae.
J Pharm & Biomed Analysis. 2011, 56, 830-835.

The Effect of pH on PAMAM Dendrimer-siRNA Complexation – Endosomal Considerations as Determined by Molecular Dynamics Simulation
Defang Ouyang, Hong Zhang, Harendra S. Parekh* and Sean C. Smith*
Biophysical Chemistry 2011, 158, 126-133.

 Neha Shah, Raymond Steptoe*, Harendra S. Parekh*.
Low generation asymmetric dendrimers exhibit minimal toxicity and effectively complex DNA.
Journal of Peptide Science, 2011, 17(5), 1-9.

Book title: Nanotechnology in Health Care
Chapter title: Introduction to Dendrimers – versatile vectors for drug and gene delivery
H.S. Parekh
Publisher: SP Publications, Jaipur, India (2011)
ISBN: 978-93-80018-02-1

Book title: Nanotechnology in Health Care
Chapter title: Dendrimers as carriers for the effective delivery of drugs and genes.
Neha Shah, Defang, Ouyang, Srinivas Mutalik, H.S. Parekh*
Publisher: SP Publications, Jaipur, India (2011)
ISBN: 978-93-80018-02-1

Book Title: Evidence-based Anticancer Herbal Medicine
Chapter title: An evidence-based perspective of herbal remedies for cancer patients
H.S. Parekh*, J. Jing
Publisher: Springer (2011)
ISBN: 9789400705258

Defang Ouyang, Hong Zhang, Dirk-Peter Herten, Harendra S. Parekh*, Sean C. Smith*.
Structure, Dynamics, and Energetics of siRNA-Cationic Vector Complexation: A Molecular Dynamics Study.
Journal of Physical Chemistry B. 2010, 114, 9220–9230.

Defang Ouyang, Hong Zhang, Harendra S. Parekh*, Sean C. Smith*.
Structure and Dynamics of Multiple Cationic Vectors-siRNA Complexation by All-Atomic Molecular Dynamics Simulations.
Journal of Physical Chemistry B. 2010, 114, 9231–9237.

Tathagata Dutta, Melinda Burgess, Nigel A.J. McMillan, Harendra S. Parekh*.
Dendrosome based delivery of siRNA against E6/E7 oncogenes in cervical cancer
Nanomedicine: Nanotechnology, Biology and Medicine 2010, 6(3), 463-470.

Defang Ouyang, Neha Shah, Harendra S. Parekh*
Reducible Disulfide-based Non-viral Gene Delivery Systems
Mini-reviews in Medicinal Chemistry 2009, 9 (10), 1242-1250.

Defang Ouyang, Hong Zhang, Harendra S. Parekh, Sean C. Smith*
Flexibility of Short-Strand RNA in Aqueous Solution as Revealed by Molecular Dynamics Simulation: Are A-RNA and A’-RNA Distinct Conformational Structures?
Australian Journal of Chemistry 2009, 62, 1054-1061.

Mutalik S, Hewavitharana AK, Shaw PN, Anissimov YG, Roberts MS, Parekh HS*
Development and validation of a reversed-phase high-performance liquid chromatographic method for quantification of peptide dendrimers in human skin permeation experiments
Journal of Chromatography B, 2009, 877 (29), 3556-62.

Harendra S. Parekh*, Ming Q. Wei, Gang Liu.
A New Dawn for the use of Traditional Chinese Medicine in Cancer Therapy.
Molecular Cancer 2009, 8(22), 1-8.

Mutalik S*, Parekh HS, Davies NM, Udupa N.
A Combined Approach of Chemical Enhancers and Sonophoresis for the Transdermal Delivery of Tizanidine Hydrochloride.
Drug Delivery 2009, 16(2), 82-91.

H. S. Parekh*
The Advance of Dendrimers – a versatile targeting platform for gene/drug delivery.
Current Pharmaceutical Design, 2007, 13(27), 2837-2850.

H.S. Parekh*, R.J. Marano, P. E Rakoczy, J. Blanchfield, I. Toth.
Synthesis of a Library of Polycationic Lipid Core Dendrimers and their Evaluation in the Delivery of an Oligonucleotide with hVEGF Inhibition.
Bioorganic Medicinal Chemistry, 2006, 14, 4775-4780.